Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 355 (6331)

See allHide authors and affiliations

Sci. Signal.  28 Mar 2017:
Vol. 10, Issue 472, eaan2959
DOI: 10.1126/scisignal.aan2959

This week’s articles describe a nonimmune function for macrophages in forming pigment stripes in fish skin, regulation of mTORC1 signaling by cholesterol, how the age-related reduction of a cofactor could affect DNA repair, the role of pulling forces in Notch activation, an epigenetic mechanism that contributes to tumor cell resistance to PI3K inhibitors, and structural analysis of an NMDA receptor.

CANCER

Chromatin state dictates drug response

Toska et al. show that tumor cells develop resistance to a drug used to treat breast cancer through a chromatin remodeling mechanism.

AGING

NAD+ binding modulates protein interactions

Liet al. demonstrate that NAD+ can influence DNA repair by modulating protein interactions.

DEVELOPMENT

Cell projections set up pigment pattern

Eom et al. found that macrophages organize pigment cells during zebrafish stripe development (see also Guilliams).

METABOLISM

Lysosomal cholesterol activates mTORC1

Castellano et al. report that a cholesterol-mTORC1 axis may play a role in metabolic homeostasis in normal and disease states.

BIOCHEMISTRY

Tugging on Notch receptor tunes signaling

Luca et al. show how mechanical forces on Notch receptors can modulate receptor signaling.

Added complexity in an asymmetric receptor

et al. found that having three different subunits allows complex regulation of the neuronal NMDA ionotropic glutamate receptor involved in synaptic plasticity.

Highlighted Articles

View Abstract

Navigate This Article