Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 355 (6332)

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Sci. Signal.  04 Apr 2017:
Vol. 10, Issue 473, eaan3462
DOI: 10.1126/scisignal.aan3462

This week’s articles highlight the role of immune cell signaling heterogeneity in aging, the unlocking of poised chromatin states in migrating cells after they reach their destination, and insight into the mechanism by which PD-1–targeted immunotherapy is effective in killing cancer cells and eliminating chronic viral infections.

IMMUNOTHERAPY

CD28 is a critical target for PD-1 blockade

Immunotherapeutic PD-1–targeted therapies require CD28 to promote cancer cell killing.

IMMUNOGENOMICS

Aging and variability among immune cells

Single-cell sequencing of mouse immune cells reveals how aging destabilizes a conserved transcriptional activation program.

NEURODEVELOPMENT

The epigenetics of face-making

Different developmental programs are unlocked when the migrating cells near their final location and interact with local patterning signals.

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