Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 543 (7647)

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Sci. Signal.  04 Apr 2017:
Vol. 10, Issue 473, eaan3518
DOI: 10.1126/scisignal.aan3518

This week’s articles highlight how cancer stem cells drive metastasis, but not primary tumor growth, and how a mitochondrial protein changes lipid metabolism to inhibit the proliferation of breast cancer cells.

CANCER

Lgr5-positive cells drive metastasis

de Sousa e Melo et al. found that deletion of cancer stem cells expressing the GPCR Lrg5 from mouse intestinal tumors did not prevent tumor growth, but instead prevented metastisis to the liver (see also Greten).

Mitochondrial lipid metabolism and tumorigenesis

Keckesova et al. show that the mitochondrial protein LACTB suppresses the proliferation of breast cancer cells by altering lipid metabolism and differentiation state.

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