Research ResourceBiochemistry

Genomics and evolution of protein phosphatases

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Sci. Signal.  11 Apr 2017:
Vol. 10, Issue 474, eaag1796
DOI: 10.1126/scisignal.aag1796

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Evolution of the diverse phosphatome

Protein kinases and protein phosphatases are two sides of a major posttranslational mode of regulation, and dysfunction in either underlies many human diseases. Relative to kinases, protein phosphatases are more structurally and catalytically diverse. Using genomic data on protein phosphatases across eukaryotic animal kingdoms, Chen et al. created a human protein phosphatome and a map of its evolution. They also tabulated disease associations with various human phosphatases. The findings provide a rich resource for exploring the phosphatome in development, physiology, and human disease.