Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine 9 (384)

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Sci. Signal.  11 Apr 2017:
Vol. 10, Issue 474, eaan3929
DOI: 10.1126/scisignal.aan3929

This week’s articles reveal how drugs that prime the tumor stroma can enhance chemotherapy and how disrupting select chemokine interactions might treat inflammatory disease.

CANCER

ROCK-ing pancreatic cancer to the core

Vennin et al. used a clinically approved drug that inhibits the kinase ROCK to decrease tension in the tumor stroma and improve chemotherapeutic efficacy against pancreatic cancer.

INFLAMMATION

Hampering heterodimers interrupts inflammation

Upon mapping the chemokine interactome, von Hundelshausen et al. discovered that inhibiting the formation of selective chemokine heterodimers may be therapeutic for patients with inflammatory disease.

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