Editors' ChoiceImmunology

Papers of note in Science Immunology 2 (10)

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Sci. Signal.  02 May 2017:
Vol. 10, Issue 477, eaan5445
DOI: 10.1126/scisignal.aan5445

This month’s articles show that cholesterol-based ligands position splenic dendritic cells near T cells; how synovial fibroblasts and neutrophils promote inflammation in arthritis; that type I interferon activates liver T cells in obese mice; and how the alternative complement pathway plays a role in antibacterial immunity.

DENDRITIC CELLS

Cholesterol marks the spot

Lu et al. showed that two cholesterol-based ligands activate the chemoattractant receptor EBI2 to properly position dendritic cells near T cells in the spleen.

RHEUMATOID ARTHRITIS

NETs blow the joint

Carmona-Rivera et al. showed that citrullinated peptides in neutrophil extracellular traps (NETs) are internalized by synovial fibroblasts and promote inflammation.

METABOLIC DISEASE

Liver T cells—The missing link in obesity-associated diabetes

Ghazarian et al. showed that the activation of CD8+ T cells in the liver by type I interferon correlates with insulin resistance in mouse models of obesity (see Ma and Greten).

COMPLEMENT

Inter-innate cooperation

Narni-Mancinelli et al. showed that cooperation between innate lymphoid cells and the alternative complement pathway protects against bacterial infections.

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