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Research ArticleImmunology
Tetraspanin microdomains control localized protein kinase C signaling in B cells
- Malou Zuidscherwoude1,*,
- Vera-Marie E. Dunlock1,*,
- Geert van den Bogaart1,
- Sjoerd J. van Deventer1,
- Alie van der Schaaf1,
- Jenny van Oostrum2,
- Joachim Goedhart3,
- Joanna In ‘t Hout4,
- Günter J. Hämmerling5,
- Satoshi Tanaka6,
- André Nadler7,
- Carsten Schultz8,
- Mark D. Wright9,
- Merel J. W. Adjobo-Hermans2, and
- Annemiek B. van Spriel1,†
- 1Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
- 2Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
- 3Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, 1098 XH Amsterdam, Netherlands.
- 4Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, 6500 HB Nijmegen, Netherlands.
- 5Department of Molecular Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
- 6Department of Pathology, Sapporo Medical University School of Medicine, 060-8556 Sapporo, Japan.
- 7Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
- 8Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
- 9Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.
- ↵†Corresponding author. Email: annemiek.vanspriel{at}radboudumc.nl
↵* These authors contributed equally to this work.
+ See all authors and affiliations
Sci. Signal. 09 May 2017:
Vol. 10, Issue 478, eaag2755
DOI: 10.1126/scisignal.aag2755
Vol. 10, Issue 478, eaag2755
DOI: 10.1126/scisignal.aag2755
Malou Zuidscherwoude
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Vera-Marie E. Dunlock
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Geert van den Bogaart
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Sjoerd J. van Deventer
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Alie van der Schaaf
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Jenny van Oostrum
Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Joachim Goedhart
Swammerdam Institute for Life Sciences, Section of Molecular Cytology, van Leeuwenhoek Centre for Advanced Microscopy, University of Amsterdam, 1098 XH Amsterdam, Netherlands.
Joanna In ‘t Hout
Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, 6500 HB Nijmegen, Netherlands.
Günter J. Hämmerling
Department of Molecular Immunology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Satoshi Tanaka
Department of Pathology, Sapporo Medical University School of Medicine, 060-8556 Sapporo, Japan.
André Nadler
Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.
Carsten Schultz
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Mark D. Wright
Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia.
Merel J. W. Adjobo-Hermans
Department of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
Annemiek B. van Spriel
Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
