Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 356 (6337)

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Sci. Signal.  09 May 2017:
Vol. 10, Issue 478, eaan5820
DOI: 10.1126/scisignal.aan5820

This week’s articles address the role of macrophage metabolic reprogramming in resolving inflammation and an epidermal pattern formation system that is self-organizing and can adjust to fit the size of the tissue.

INFLAMMATION

A way to switch off IBD

Ip et al. found that an interleukin controls a metabolic switch in macrophages that inhibits a signaling pathway, thereby suppressing intestinal inflammation (see also Kabat and Pearce).

NEURODEVELOPMENT

Self-organization for sensory brushes

Corson et al. showed that distributed and flexible patterning combines with cell-cell interactions to establish rows of sensory bristles on the fly thorax.

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