Editors' ChoiceNEURODEGENERATIVE DISEASE

Paper of note in Science Translational Medicine 9 (388)

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Sci. Signal.  09 May 2017:
Vol. 10, Issue 478, eaan5860
DOI: 10.1126/scisignal.aan5860

This week’s article uncovers why mutations in the vesicular trafficking protein annexin 11 are implicated in the neurodegenerative disease ALS.

AMYOTROPHIC LATERAL SCLEROSIS

Annexing another protein in ALS pathogenesis

Smith et al. showed that mutations in ANXA11, found in patients with amyotrophic lateral sclerosis (ALS), promote aggregation of the Golgi-to-ER vesicular trafficking protein annexin A11 in spinal motor and hippocampal neurons, potentially through impaired binding to the proteasome-associated protein calcyclin.

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