Research ResourceHost-Microbe Interactions

The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways

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Sci. Signal.  16 May 2017:
Vol. 10, Issue 479, eaal4501
DOI: 10.1126/scisignal.aal4501

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Vibrio survives by rewiring host cell signaling

Vibrio parahaemolyticus (V. para) is a major cause of food poisoning caused by eating raw or undercooked shellfish. Like other types of bacteria, V. para delivers effectors into host cells through type 3 secretion systems (T3SSs). Those delivered through T3SS1 cause nonapoptotic death in various cultured cells. De Nisco et al. analyzed the transcriptional response of primary human fibroblasts to infection with a strain of V. para that has an intact T3SS1, which enables the bacterium to survive in its natural habitat, but lacks T3SS2, which mediates gastroenteritis in humans. V. para T3SS1 induced a rapid, dynamic transcriptional response that initially suppressed cell death and stimulated cell survival networks. Later in infection, effectors delivered through T3SS1 inhibited prosurvival signaling posttranslationally and induced cell death.

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