Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 545 (7653)

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Sci. Signal.  16 May 2017:
Vol. 10, Issue 479, eaan6400
DOI: 10.1126/scisignal.aan6400

This week’s articles highlight colon cancer stem cells; cooperative signaling that maintains intestinal stem cell self-renewal; a newly developed Wnt agonist; and metabolic changes in endothelial cells that promote angiogenesis.

CANCER

Targeting colon cancer stem cells

Shimokawa et al. found that a specific subset of human colorectal cancer cells act as cancer stem cells and are targeted by combined chemotherapy.

PHARMACOLOGY

Functional Wnt agonists

Janda et al. developed agonists that stimulate Wnt signaling by forcing its receptor and co-receptor to heterodimerize in the absence of ligand.

STEM CELLS

Cooperation between Wnts and R-spondins

Yan et al. found that Wnt and R-spondin cooperate to control intestinal stem cell self-renewal but are not redundant.

VASCULAR BIOLOGY

FGF signaling and cellular metabolism

Yu et al. showed that FGF signaling promotes angiogenesis by stimulating glycolysis in endothelial cells.

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