Contents
16 May 2017
Vol 10, Issue 479
Vol 10, Issue 479
Research Article
- Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes
ROS promote blood vessel formation in the placenta, which protects against preeclampsia.
Research Resource
- The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways
The pathogenic bacterium Vibrio parahaemolyticus manipulates death and survival networks in host cells to ensure its survival.
Podcast
- Science Signaling Podcast for 16 May 2017: Vibrio rewires host cells
The type 3 secretion system 1 of Vibrio parahaemolyticus initially rewires host cell signaling networks to promote cell survival, then later kills the host cell (De Nisco et al. in 16 May 2017 issue).
Editors' Choice
- Quorum sensing to repress virulence
A quorum-sensing system of an insect endosymbiont enables the bacterium to establish persistent infection by inhibiting the expression of virulence genes.
- New connections: The duality of ROS in angiogenesis
Depending on the tissue and context, ROS can either stimulate or suppress blood vessel formation.
- Papers of note in Science 356 (6338)
This week’s articles demonstrate how T cells search for ligands; a role for the endoplasmic reticulum in the nonclathrin-mediated endocytosis of a growth factor receptor; and growth coupling between distant bacterial colonies that enables the cells to share limited resources.
- Papers of note in Science Translational Medicine 9 (389)
This week’s articles highlight how tumor-associated macrophages limit the efficacy of PD-1–targeted checkpoint therapy and show that an anti-inflammatory drug may be used to treat lymphedema.
- Papers of note in Nature 545 (7653)
This week’s articles highlight colon cancer stem cells; cooperative signaling that maintains intestinal stem cell self-renewal; a newly developed Wnt agonist; and metabolic changes in endothelial cells that promote angiogenesis.
Erratum
About The Cover
Online Cover This week features a Research Resource that shows how the pathogenic bacterium Vibrio parahaemolyticus rewires host cell signaling networks. The image shows Vibrio parahaemolyticus cells. [Image: Science Source]