Vol 10, Issue 479
- Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes
ROS promote blood vessel formation in the placenta, which protects against preeclampsia.
- The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways
The pathogenic bacterium Vibrio parahaemolyticus manipulates death and survival networks in host cells to ensure its survival.
The type 3 secretion system 1 of Vibrio parahaemolyticus initially rewires host cell signaling networks to promote cell survival, then later kills the host cell (De Nisco et al. in 16 May 2017 issue).
This week’s articles demonstrate how T cells search for ligands; a role for the endoplasmic reticulum in the nonclathrin-mediated endocytosis of a growth factor receptor; and growth coupling between distant bacterial colonies that enables the cells to share limited resources.
This week’s articles highlight how tumor-associated macrophages limit the efficacy of PD-1–targeted checkpoint therapy and show that an anti-inflammatory drug may be used to treat lymphedema.
This week’s articles highlight colon cancer stem cells; cooperative signaling that maintains intestinal stem cell self-renewal; a newly developed Wnt agonist; and metabolic changes in endothelial cells that promote angiogenesis.
- Erratum for the Research Article: “Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus” by I. A. Buskiewicz, T. Montgomery, E. C. Yasewicz, S. A. Huber, M. P. Murphy, R. C. Hartley, R. Kelly, M. K. Crow, A. Perl, R. C. Budd, A. Koenig
Table 1 has been updated.