Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 356 (6339)

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Sci. Signal.  23 May 2017:
Vol. 10, Issue 480, eaan6823
DOI: 10.1126/scisignal.aan6823

This week’s articles identify a repulsive guidance system that controls the recruitment of T cells to germinal centers; a mechanism for controlling the transfer of nutrients from the placenta to early mouse embryos; and the subcellular location of calcium dynamics in astrocytes.

GERMINAL CENTERS

Guiding immune cells to the center

Lu et al. showed that a repulsive guidance system is involved in immunological T cell recruitment to the sites of antibody affinity maturation (see also Moschovakis and Förster).

DEVELOPMENT BIOLOGY

Embryo viability relies on placental repression

Yang et al. found that ZFP568 is a direct repressor of the placental insulin-like growth factor 2 promoter transcript during mouse development.

NEUROSCIENCE

Glial calcium dynamics in space and time

Bindocci et al. developed a two-photon imaging technique that enables the measurement of calcium dynamics in neuronal glial cells in three dimensions.

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