Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 545 (7655)

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Sci. Signal.  30 May 2017:
Vol. 10, Issue 481, eaan8308
DOI: 10.1126/scisignal.aan8308

This week’s articles focus on cancer immunotherapy, the plant immune response, and the human protein interactome.

CANCER

PD-1 suppresses macrophages, too

Gordon et al. found that blocking the immune checkpoint receptor PD-1 not only improves the antitumor activity of T cells but also improves the antitumor response of macrophages.

Engineered T cells

Sadelain et al. review the potential for using engineered T cells to treat cancer, particularly T cells bearing chimeric antigen receptors.

PLANT BIOLOGY

Targeting translation to improve crops

Two papers from Xu et al. report that the plants immune response involves translational reprogramming and that this process may be targeted to increase disease resistance in crops (see also Bailey-Serres and Ma).

PROTEOMICS

Exploring the human protein interactome

Huttlin et al. combined affinity purification and mass spectrometry to identify 1,320 human protein interaction networks relevant to cellular regulation or disease.

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