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Papers of note in Science Translational Medicine 9 (392)

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Sci. Signal.  06 Jun 2017:
Vol. 10, Issue 482, eaan8796
DOI: 10.1126/scisignal.aan8796

This week’s articles describe a new drug conjugate to treat pain, a target for preventing cognitive decline in Alzheimer’s disease, and a strategy for sensitizing RAS-mutant cancers to PARP inhibitors.

PAIN

Targeting the enemy within endosomes

Jensen et al. demonstrate that blocking endocytosis of the neurokinin 1 receptor blocks pain transmission in spinal neurons.

CANCER

No escape for KRAS mutant tumors

Sun et al. report that inhibition of the kinases MEK or ERK sensitizes various KRAS-mutant tumors to PARP inhibitors.

ALZHEIMER’S DISEASE

Avoiding complements

Shi et al. show that blocking complement signaling protects against synapse loss and cognitive decline in a mouse model of Alzheimer’s disease.

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