Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 546 (7656)

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Sci. Signal.  06 Jun 2017:
Vol. 10, Issue 482, eaan8811
DOI: 10.1126/scisignal.aan8811

This week’s articles highlight the role of follicle-stimulating hormone in postmenopausal adipose tissue accumulation, the importance of a sphingolipid for T cell survival, and the cryo-EM structure of a G protein–coupled receptor complex.

PHYSIOLOGY

Blocking FSH to offset the effects of menopause

Liu et al. found that, in addition to increasing bone mass, an antibody that blocks follicle-stimulating hormone reduced adiposity and stimulated brown fat in mice, suggesting a potential strategy for treating both the bone loss and fat gain associated with menopause.

IMMUNOLOGY

Fueling T cell migration

Mendoza et al. show that the sphingolipid S1P maintains the high mitochondrial function that supports the constant migration of T cells.

BIOCHEMISTRY

Class B GPCR complex in focus

Liang et al. report the cryo-EM structure of a class B G protein–coupled receptor in complex with its ligand and heterotrimeric G protein (see also Tsai et al.).

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