Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 356 (6343)

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Sci. Signal.  20 Jun 2017:
Vol. 10, Issue 484, eaao1166
DOI: 10.1126/scisignal.aao1166

This week’s articles describe a mechanism by which starvation primes a cellular nutrient-sensing system for activation upon refeeding; microRNAs that control pain sensitivity; and the lasting effects of early life stress on the likelihood of developing depression.

CELLULAR METABOLISM

Preparing for the feast during the fast

Di Malta et al. report on a transcriptional regulatory mechanism that enables cellular adaptation to nutrient availability and supports cancer metabolism.

NEUROSCIENCE

MicroRNAs in functional and dysfunctional pain

Peng et al. describe a cluster of microRNAs that regulate both normal pain sensitivity and the pathological responses of chronic pain (see also Cassels and Barde).

Early life stress in depression susceptibility

Peña et al. identify an early window of stress susceptibility that defines a mouse’s response to stress in adulthood.

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