Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 356 (6344)

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Sci. Signal.  27 Jun 2017:
Vol. 10, Issue 485, eaao1817
DOI: 10.1126/scisignal.aao1817

This week’s articles address the biochemistry of PKA activation, neuronal signaling that controls whether worms are awake or asleep, and how gut microbial metabolism modifies the effects of nutrients, drugs, and toxins on the host.

BIOCHEMISTRY

PKA-activation mechanism revised

Smith et al. reveal how cyclic AMP–dependent protein kinase A really works.

NEUROSCIENCE

Neuronal basis of lethargy in worms

Nichols et al. performed brain imaging in nematode mutants to reveal how a brain switches between alert wakefulness and sleep.

MICROBIOTA

One person's meat is another's poison

A review from Koppel et al. explains that molecular understanding of microbial xenobiotic metabolism will enable personalized nutrition, toxicology, and medicine.

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