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Papers of note in Science Translational Medicine 9 (396)

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Sci. Signal.  04 Jul 2017:
Vol. 10, Issue 486, eaao2249
DOI: 10.1126/scisignal.aao2249

This week’s articles describe ways to potentially treat lymphoma and fatty liver–associated fibrosis.

CANCER

Lymphoma’s loss is a therapeutic gain

Oricchio et al. discover that loss of SESTRIN1 expression drives mTORC1 signaling in lymphoma cells and that drugs inhibiting EZH2 may be therapeutic in patients by restoring the abundance of SESTRIN.

FIBROSIS

Opposing cytokines in obesity and fibrosis

Hart et al. report that inhibiting the growth factor TGF-β and the cytokine IL-13 may suppress the development of fibrosis in patients with nonalcoholic fatty liver disease.

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