Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 546 (7660)

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Sci. Signal.  04 Jul 2017:
Vol. 10, Issue 486, eaao2378
DOI: 10.1126/scisignal.aao2378

This week’s articles highlight a mechanism by which melanoma cells prepare the metastatic niche, intestinal defense against rotavirus, and immune tolerance in the human fetus.

CANCER

Melanomas prep the premetastatic niche

Olmeda et al. found that melanoma cells secrete a growth factor that stimulates lymphangiogenesis in distant tissues, thus preparing the premetastatic niche (see also Hoshino and Lyden).

IMMUOLOGY

How intestinal cells battle rotavirus

Zhu et al. identified the subset of inflammasomes that mediate intestinal defense against rotavirus infection (see also Saavedra and Lamkanfi).

Tolerance in the fetal immune system

McGovern et al. report that a subset of dendritic cells in the human fetus promotes immune tolerance in part by degrading an amino acid that is required for the production of the proinflammatory cytokine TNF-α.

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