Letter

Editorial expression of concern

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Sci. Signal.  18 Jul 2017:
Vol. 10, Issue 488, eaao2123
DOI: 10.1126/scisignal.aao2123

In the 10 May 2016 issue, Science Signaling published the Research Article “The transcription factor FOXF1 promotes prostate cancer by stimulating the mitogen-activated protein kinase ERK5” by L. Fulford, D. Milewski, V. Ustiyan, N. Ravishankar, Y. Cai, T. Le, S. Masineni, S. Kasper, B. Aronow, V. V. Kalinichenko, T. V. Kalin (1). The corresponding author and the research integrity officer of the corresponding author’s institution notified Science Signaling that there was concern about image manipulation in Fig. 2C (images of caspase-3 staining) and fig. S4E (Western blots) and that an investigation is under way to determine if this represents research misconduct and to examine the data in other figures of the paper. Science Signaling is publishing this Editorial Expression of Concern to alert our readers while we await the outcome of the investigation.

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