Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 547 (7662)

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Sci. Signal.  18 Jul 2017:
Vol. 10, Issue 488, eaao3805
DOI: 10.1126/scisignal.aao3805

This week’s articles describe mechanisms that control the proliferation of cardiac cells during injury repair, personalized vaccines for treating cancer, and a mechanism by which malaria parasites sense host nutrients.

CARDIOVASCULAR BIOLOGY

Controlling cardiomyocyte proliferation

Bassat et al. found that the extracellular matrix component agrin promotes proliferation of cardiomyocytes and cardiac regeneration by stimulating ERK signaling and nuclear translocation of the transcriptional coactivator Yap downstream of the receptor Dag1. In a related paper, Morikawa et al. report that association with Dag1 sequesters Yap in the cytoplasm to prevent inappropriate proliferation of cardiomyocytes. See also Eroglu and Chien.

CANCER

Melanoma therapy gets personal

Ott et al. and Sahin et al. report clinical success in treating melanoma using personalized vaccines based on tumor-specific neoantigens (see also Melief).

PARASITOLOGY

Noncanonical nutrient sensing

Mancio-Silva et al. demonstrate that the malaria parasite Plasmodium senses and responds to host nutrients using a conserved cellular energy–sensing pathway.

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