Research ResourceImmunology

A cluster of immunoresolvents links coagulation to innate host defense in human blood

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Sci. Signal.  01 Aug 2017:
Vol. 10, Issue 490, eaan1471
DOI: 10.1126/scisignal.aan1471

Linking clots to immunity

The threats to the host posed by barrier breach are counteracted by blood coagulation and the formation of blood clots, processes that are accompanied by inflammation and then tissue regeneration and wound healing. Arachidonic acid–derived prostaglandins and leukotrienes play important prothrombotic and inflammatory roles early in the process, which lead to the generation of other lipid mediators known as specialized proresolving mediators (SPMs), which are important for resolution. Norris et al. used metabololipidomics and mass cytometry–based analyses to identify a functional cluster of SPMs generated at the late stages of human blood coagulation. Treatment of whole blood with these particular SPMs stimulated distinct signaling pathways within specific cell types and enhanced the uptake and killing of bacteria by phagocytic cells. Together, these data connect factors generated by blood coagulation to immune responses that protect the host.