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Papers of note in Science Translational Medicine 9 (400)

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Sci. Signal.  01 Aug 2017:
Vol. 10, Issue 490, eaao4937
DOI: 10.1126/scisignal.aao4937

This week’s articles describe new strategies to selectively target therapeutics to tumors.

CANCER THERAPY

A stiff punishment for tumors

Liu et al. engineered mechanoresponsive mesenchymal stem cells to act as vehicles for tumor-targeted drug delivery.

BET-ting on a new drug combination

Yang et al. discovered that inhibiting the epigenetic regulator BET causes a DNA repair deficiency that sensitizes tumors to PARP inhibitors.

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