Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 357 (6349)

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Sci. Signal.  01 Aug 2017:
Vol. 10, Issue 490, eaao5008
DOI: 10.1126/scisignal.aao5008

This week’s articles identify a mechanism that targets incompletely translated polypeptides for degradation and review the various roles of a class of dietary tryptophan metabolites in health and disease.

PROTEOSTASIS

A tale of CAT tails

Kostova et al. report that elongation of stalled peptides during protein translation promotes degradation by the ribosome quality control complex.

METABOLISM

From stomach ache to depression

In a review, Cervenka et al. explain that tryptophan metabolites integrate the cross-talk between metabolic, microbial, immune, and neural systems.

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