Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 547 (7664)

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Sci. Signal.  01 Aug 2017:
Vol. 10, Issue 490, eaao5009
DOI: 10.1126/scisignal.aao5009

This week’s articles highlight mechanisms that sensitize cancer cells to therapy; a protease involved in radiation-induced bystander effects; the structural basis of cannabinoid receptor activation; and the detection of water currents by fish.

CANCER

Sensitizing tumor cells to immunotherapy

Manguso et al. demonstrate that loss of the protein tyrosine phosphatase PTPN2 sensitizes tumor cells to immunotherapy by stimulating interferon-γ signaling.

A vulnerability of therapy-resistant tumors

Viswanathan et al. show that many different types of therapy-resistant cancer cells are sensitive to ferroptosis induced by the inhibition of lipid peroxidation.

CELL BIOLOGY

Inducing bystander effects

Peng et al. identify a homolog of the human cysteine protease cathepsin B as the secreted factor that mediates radiation-induced bystander effects in nematodes.

STRUCTURAL BIOLOGY

How cannabinoids activate their receptor

Hua et al. used crystal structures of cannabinoid receptor 1 bound to two different agonists to gain insight into the activation mechanism of this receptor.

PHYSIOLOGY

How fish sense currents

Oteiza et al. show how mechanosensory lateral line cells enable fish to orient themselves in a current in the absence of visual cues (see also Dabiri).

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