Editors' ChoiceImmunology

Papers of note in Science Immunology 2 (13)

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Sci. Signal.  01 Aug 2017:
Vol. 10, Issue 490, eaao5135
DOI: 10.1126/scisignal.aao5135

This month’s articles show how agonists of the STING-cGAS pathway in dendritic cells might serve as vaccine adjuvants and how tumor-derived exosomes increase the abundance of an immunosuppressive molecule on monocytes.

VACCINES

Successful vaccination through “pseudo” science

Kim et al. showed that lentiviral vectors stimulate immune responses by pseudotransduction and activation of the STING-cGAS pathway, suggesting that agonists of this pathway may serve as vaccine adjuvants.

CANCER

Messaging with RNAs

Haderk et al. showed that exosomes released from chronic lymphocytic leukemia cells contained RNAs that promoted monocytes to adopt an immunosuppressive phenotype, including the expression of the immune checkpoint protein programmed death ligand 1.

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