Research ArticleMetabolism

TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis

See allHide authors and affiliations

Sci. Signal.  08 Aug 2017:
Vol. 10, Issue 491, eaal3336
DOI: 10.1126/scisignal.aal3336

Article Information

vol. 10 no. 491

Published By: 
Print ISSN: 
Online ISSN: 
  • Received November 4, 2016
  • Resubmitted April 13, 2017
  • Accepted July 21, 2017

Author Information

  1. Jing Chen1,2,*,
  2. Jin Li1,3,4,*,
  3. Jensen H. C. Yiu1,2,
  4. Jenny K. W. Lam2,
  5. Chi-Ming Wong1,3,
  6. Bernhard Dorweiler5,
  7. Aimin Xu1,2,3,, and
  8. Connie W. Woo1,2,
  1. 1State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong 999077, China.
  2. 2Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong 999077, China.
  3. 3Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China.
  4. 4Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
  5. 5Division of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center Mainz, Mainz 55131, Germany.
  1. Corresponding author. Email: cwhwoo{at} (C.W.W.); amxu{at} (A.X.)
    • * These authors contributed equally to this work.


    Article usage

    Aug 20173978128226
    Sep 20171954739
    Oct 201777513