Research ResourceCancer

Breast tumors educate the proteome of stromal tissue in an individualized but coordinated manner

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Sci. Signal.  08 Aug 2017:
Vol. 10, Issue 491, eaam8065
DOI: 10.1126/scisignal.aam8065

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Profiling the tumor stroma proteome

Communication between a tumor and cells in the surrounding stroma contributes to tumor growth, progression, and drug resistance. Thus, targeting this communication, in the primary tumor and especially in metastatic niches, may be an effective way to treat cancer. Wang et al. grew patient breast tumors subcutaneously in mice and obtained species-distinguished proteomic profiles of the tumors (human) and tumor-associated stroma (mouse). The authors found that all breast tumors consistently altered clustered subsets of the stromal proteome, particularly proteins involved in immune signaling, but that these varied in a subtype- and stage-specific manner. These findings may have future implications for treatment stratification and provide a platform from which to understand this experimental model and tumor-stroma interactions on a large-scale protein level.