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Papers of note in Science Translational Medicine 9 (402)

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Sci. Signal.  15 Aug 2017:
Vol. 10, Issue 492, eaao6262
DOI: 10.1126/scisignal.aao6262

This week’s articles describe a way to prevent a major side effect of chemotherapy, paths of endocrine therapy resistance in breast cancer, and a new treatment for type 1 diabetes.

CANCER

Rock-a-bye bone marrow

Taylor et al. report that inhibitors of the kinase FLT3 might be used to protect the bone marrow during chemotherapy.

A patient look at cancer resistance

Giltnane et al. analyze patients’ breast tumors after estrogen-blocking therapy and find new targets to prevent drug resistance.

AUTOIMMUNITY

Peptide therapy for diabetes

Alhadj Ali et al. show that an immunogenic proinsulin peptide modified T cell responses without disrupting β cell function in patients with type 1 diabetes.

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