Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 357 (6352)

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Sci. Signal.  22 Aug 2017:
Vol. 10, Issue 493, eaao7159
DOI: 10.1126/scisignal.aao7159

This week’s articles describe placental and intrinsic signals that direct development in embryos.

DEVELOPMENTAL BIOLOGY

Preventing preeclampsia in pregnancy

Ho et al. report that the placental hormone ELABELA (also known as ELA, a ligand of the apelin receptor) protects against preeclampsia and associated defects in fetal heart development.

The makings of the reproductive tract

Zhao et al. show that enhanced activation of the kinase ERK and the transcription factor COUP-TFII, not the absence of androgen as previously thought, suppresses mesenchyme-epithelium crosstalk to eliminate male reproductive tracts in female embryos.

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