Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 548 (7667)

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Sci. Signal.  22 Aug 2017:
Vol. 10, Issue 493, eaao7163
DOI: 10.1126/scisignal.aao7163

This week’s articles describe signals that underscore the development of taste sensation, T cell populations, and melanoma drug resistance.

NEUROSCIENCE

Bitter or sweet?

Lee et al. report that distinct semaphorins guide the wiring of bitter and sweet taste circuits (see Li and Luo).

IMMUNOLOGY

mRNA methylation and T cell function

Li et al. show that RNA methylation controls T cell development by facilitating decay of SOCS family mRNAs to enhance signaling between the cytokine IL-7 and the transcription factor STAT5.

CANCER

Noncoding modes of resistance

Joung et al. identify long noncoding RNAs and their targets through which they confer BRAF inhibitor resistance in melanoma cells.

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