FocusCell Biology

Ca2+ and mitochondrial ROS: Both hero and villain in membrane repair

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Sci. Signal.  05 Sep 2017:
Vol. 10, Issue 495, eaao3795
DOI: 10.1126/scisignal.aao3795

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Abstract

Membrane repair is a symphony of signaling, conducted principally by the steep influx of Ca2+ through an injured membrane. In this issue of Science Signaling, Horn et al. reveal unique interplay between Ca2+ influx and mitochondrially generated reactive oxygen species (mtROS) to enhance actin-mediated wound closure for survival of injured mammalian muscle and nonmuscle cells.

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