Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine 9 (405)

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Sci. Signal.  05 Sep 2017:
Vol. 10, Issue 495, eaap8365
DOI: 10.1126/scisignal.aap8365

This week’s articles describe how the immune system in some children is better able to cope with dengue virus infection; how targeting a specific population of monocytes may relieve persistent inflammation associated with HIV infection; and how targeting the vascular niche may suppress fibrosis around lung and liver engraftments.

IMMUNOLOGY

Distinguishing dengue presentation

Simon-Lorière et al. examined the serum and immune gene transcripts of Cambodian children with clinical or asymptomatic dengue virus infections and uncovered differences in adaptive immune system pathways that may drive pathologic responses in severe dengue virus infections.

Curbing complications in chronic HIV

Schechter et al. discover how inflammation and coagulation intersect in chronic HIV and SIV infection through a population of tissue factor–positive monocytes.

FIBROSIS

To fix fibrosis, nix the niche

Cao et al. report that targeted gene delivery and enzyme inhibition in vascular and perivascular cells promote engraftment of transplanted parenchymal cells for lung and liver repair.

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