Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 357 (6355)

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Sci. Signal.  12 Sep 2017:
Vol. 10, Issue 496, eaap8920
DOI: 10.1126/scisignal.aap8920

This week’s articles describe an alternative mechanism of secretion that is deployed by intestinal cells in the presence of pathogens; how the immune system protects the lungs from inhaled fungal spores; and metabolic reprogramming of tissue-resident antigen-presenting cells in the lung.

HOST-PATHOGEN INTERACTIONS

Foiling bad bugs' sneaky tricks

Bel et al. found that during pathogen-induced cellular stress, Paneth cells reroute a key antimicrobial protein through an autophagy-based secretion pathway (see also Kaser and Blumberg).

Survivin' neutrophil surveillance

Shlezinger et al. discovered that mold spores do not become invasive after inhalation by humans because neutrophils induce their death at germination.

INFLAMMATION

Metabolic programming of tissue APCs

Sinclair et al. report that metabolic adaptation of antigen-presenting cells in the lung reprograms lung dendritic cells and modulates allergic inflammation (see also Wiesner and Klein).

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