Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 549 (7671)

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Sci. Signal.  19 Sep 2017:
Vol. 10, Issue 497, eaap9538
DOI: 10.1126/scisignal.aap9538

This week’s articles highlight the immune response to intestinal helminth parasites and an mRNA modification that determines cell fate.

HOST-PATHOGEN INTERACTIONS

Enteric neurons sound the alarm

Cardoso et al. and Klose et al. found that the presence of helminth parasites causes enteric neurons to release a neuropeptide that stimulates innate lymphoid cells to initiate a type 2 inflammatory response.

DEVELOPMENTAL BIOLOGY

mRNA modification determines cell fate

Zhang et al. report that a specific biochemical modification of mRNAs influences the specification of the hematopoietic lineage in zebrafish embryos by affecting Notch-mediated cell fate determination.

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