Research ArticlePharmacology
Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma
- Stefan K. Zöllner1,2,
- Saravana P. Selvanathan1,
- Garrett T. Graham1,
- Ryan M. T. Commins1,
- Sung Hyeok Hong1,
- Eric Moseley1,
- Sydney Parks1,
- Jessica N. Haladyna1,
- Hayriye V. Erkizan1,
- Uta Dirksen2,
- Michael D. Hogarty3,
- Aykut Üren1, and
- Jeffrey A. Toretsky1,*
- 1Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
- 2Department of Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany.
- 3Division of Oncology, Children’s Hospital of Philadelphia, Colket Translational Research Building, Room 3020, 3501 Civic Center Boulevard, Philadelphia, PA 19014, USA.
- ↵*Corresponding author. Email: jat42{at}georgetown.edu
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Sci. Signal. 03 Oct 2017:
Vol. 10, Issue 499, eaam8429
DOI: 10.1126/scisignal.aam8429
