Research ArticlePharmacology
Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma
- Stefan K. Zöllner1,2,
- Saravana P. Selvanathan1,
- Garrett T. Graham1,
- Ryan M. T. Commins1,
- Sung Hyeok Hong1,
- Eric Moseley1,
- Sydney Parks1,
- Jessica N. Haladyna1,
- Hayriye V. Erkizan1,
- Uta Dirksen2,
- Michael D. Hogarty3,
- Aykut Üren1, and
- Jeffrey A. Toretsky1,*
- 1Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
- 2Department of Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany.
- 3Division of Oncology, Children’s Hospital of Philadelphia, Colket Translational Research Building, Room 3020, 3501 Civic Center Boulevard, Philadelphia, PA 19014, USA.
- ↵*Corresponding author. Email: jat42{at}georgetown.edu
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Sci. Signal. 03 Oct 2017:
Vol. 10, Issue 499, eaam8429
DOI: 10.1126/scisignal.aam8429
Vol. 10, Issue 499, eaam8429
DOI: 10.1126/scisignal.aam8429
Stefan K. Zöllner
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.Department of Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany.
Saravana P. Selvanathan
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Garrett T. Graham
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Ryan M. T. Commins
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Sung Hyeok Hong
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Eric Moseley
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Sydney Parks
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Jessica N. Haladyna
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Hayriye V. Erkizan
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Uta Dirksen
Department of Pediatric Hematology and Oncology, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149 Münster, Germany.
Michael D. Hogarty
Division of Oncology, Children’s Hospital of Philadelphia, Colket Translational Research Building, Room 3020, 3501 Civic Center Boulevard, Philadelphia, PA 19014, USA.
Aykut Üren
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
Jeffrey A. Toretsky
Department of Oncology and Pediatrics, Georgetown University, 3970 Reservoir Road Northwest, Washington, DC 20057, USA.
