Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine 9 (409)

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Sci. Signal.  03 Oct 2017:
Vol. 10, Issue 499, eaaq0767
DOI: 10.1126/scisignal.aaq0767

This week’s articles describe a stem cell–based therapy for chronic kidney disease and targets for treating diabetic nerve pain and acute respiratory distress in critically ill patients.

KIDNEY DISEASE

Cell therapy for renal anemia

Hitomi et al. report that transplantation of iPSC-derived cells that secrete functional erythropoietin may relieve anemia in patients with chronic kidney disease.

DIABETIC NEUROPATHY

Taking diabetic pain to heart

Tsantoulas et al. found that blocking HCN2 ion channels in peripheral sensory neurons reduces pain sensitivity in mouse models of diabetic neuropathy.

THROMBOSIS

Rip 'n’ roll

Yuan et al. show that inhibiting cell death pathways in platelets may limit neutrophil aggregation and prevent pulmonary thrombosis in patients with intestinal ischemia.

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