Research ArticleCancer Immunology

Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival

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Sci. Signal.  10 Oct 2017:
Vol. 10, Issue 500, eaam5353
DOI: 10.1126/scisignal.aam5353

Article Information

vol. 10 no. 500

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History: 
  • Received December 5, 2016
  • Accepted September 21, 2017

Author Information

  1. Matthew Gumbleton1,*,,
  2. Raki Sudan1,*,
  3. Sandra Fernandes1,
  4. Robert W. Engelman2,3,4,
  5. Christopher M. Russo5,
  6. John D. Chisholm5, and
  7. William G. Kerr1,5,6,7,
  1. 1Department of Microbiology and Immunology, State University of New York (SUNY) Upstate Medical University, Syracuse, NY 13210, USA.
  2. 2Department of Pathology and Cell Biology, University of South Florida, Tampa, FL 33612, USA.
  3. 3Department of Pediatrics, University of South Florida, Tampa, FL 33612, USA.
  4. 4H. Lee Moffitt Comprehensive Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA.
  5. 5Department of Chemistry, Syracuse University, Syracuse, NY 13210, USA.
  6. 6Department of Pediatrics, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
  7. 7Centre d’Immunologie de Marseille-Luminy, Marseille, France.
  1. Corresponding author. Email: kerrw{at}upstate.edu
    • * These authors contributed equally to this work.

    • Present address: Department of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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