Research ArticleAging

The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1

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Sci. Signal.  17 Oct 2017:
Vol. 10, Issue 501, eaaj1784
DOI: 10.1126/scisignal.aaj1784

Article Information

vol. 10 no. 501

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History: 
  • Received September 12, 2016
  • Accepted September 20, 2017

Author Information

  1. Daniel N. Meijles1,2,*,
  2. Sanghamitra Sahoo1,2,
  3. Imad Al Ghouleh1,2,3,
  4. Jefferson H. Amaral1,2,
  5. Raquel Bienes-Martinez1,
  6. Heather E. Knupp1,
  7. Shireen Attaran2,
  8. John C. Sembrat1,2,
  9. Seyed M. Nouraie4,
  10. Mauricio M. Rojas1,4,
  11. Enrico M. Novelli1,
  12. Mark T. Gladwin1,4,
  13. Jeffrey S. Isenberg1,2,4,
  14. Eugenia Cifuentes-Pagano1,2, and
  15. Patrick J. Pagano1,2,
  1. 1Pittsburgh Heart, Lung and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  2. 2Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  3. 3Division of Cardiology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  4. 4Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  1. Corresponding author. Email: pagano{at}pitt.edu
  • * Present address: Molecular and Clinical Sciences Research Institute, St. George’s University of London, London SW17 0RE, UK.

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