Editors' ChoiceCellular and Molecular Signaling

Papers of note in Science 358 (6360)

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Sci. Signal.  17 Oct 2017:
Vol. 10, Issue 501, eaar1922
DOI: 10.1126/scisignal.aar1922

This week’s articles identify distinct mechanisms of apoptosis in different areas of the germinal center and present an interactive virtual fly embryo that shows the expression of signaling pathway components and other regulatory molecules in individual cells.

IMMUNOLOGY

Light- and dark-zone death dynamics

Mayer et al. found that the selection of germinal center B cells by apoptosis is regulated by microanatomically distinct mechanisms.

SINGLE-CELL TRANSCRIPTOME

Making a fly 3D gene expression blueprint

Karaiskos et al. used single-cell sequencing to generate an interactive database that enables the generation of a 3D virtual fly embryo and gene expression blueprint.

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