Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 550 (7675)

See allHide authors and affiliations

Sci. Signal.  17 Oct 2017:
Vol. 10, Issue 501, eaar1923
DOI: 10.1126/scisignal.aar1923

The articles highlighted this week focus on signaling events that control appetite and weight; the effects of Hippo signaling on cell function during cardiac repair; a mechanism that drives cancer drug addiction; inactivation of a kinase complex by structural rearrangement; and the mechanism by which a noncoding viral RNA inhibits host cell apoptosis.

OBESITY

How GDF15 controls body weight

Hsu et al. found that the growth factor GDF15 signals through the receptor GFRAL in the brainstem to control appetite and body weight through a neuronal circuit that mediates weight loss during stress and disease (see also Saarma and Goldman).

CARDIAC REPAIR

Stimulating cell function during regeneration

Leach et al. demonstrate that inactivation of Hippo signaling promotes cardiac repair in mice with established ischemic heart failure by stimulating cardiomyocyte function and proliferation.

CANCER

Mechanism of cancer drug addiction

Kong et al. found that cancer drug–addicted melanoma cells rely on ERK2 for survival and undergo an ERK2-dependent phenotype switch before they undergo cell death in response to withdrawl of the drug (see also Lee and Marais).

CELL BIOLOGY

Inactivation by reorganization

Prouteau et al. report that glucose withdrawal causes a structural reorganization of yeast TORC1 that suppresses the kinase activity of this TOR complex.

Viral noncoding RNA blocks cell death

Gorbea et al. identified a noncoding RNA from a herpesvirus that promotes the survival of infected cells by recruiting host microRNAs to mRNAs that encode proapoptotic proteins.

Highlighted Articles

View Abstract

Navigate This Article