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Papers of note in Science Translational Medicine 9 (412)

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Sci. Signal.  24 Oct 2017:
Vol. 10, Issue 502, eaar2008
DOI: 10.1126/scisignal.aar2008

This week’s articles describe ways to potentially treat obesity-associated disorders and prevent sepsis.

OBESITY

A treatment for obesity

Xiong et al. report that delivery of the TGF-β superfamily protein GDF15 treats obesity in mice and monkeys.

SEPSIS

Taking the STING out of sepsis

Zeng et al. show that drugs inhibiting the kinase ALK protect mice against sepsis by attenuating the activation of STING signaling in innate immune cells.

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