Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 550 (7676)

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Sci. Signal.  24 Oct 2017:
Vol. 10, Issue 502, eaar2567
DOI: 10.1126/scisignal.aar2567

This week’s articles identify a mechanism that establishes the senescence-associated secretory phenotype and reveal details about the gating of TRPML channels.

CELL BIOLOGY

Inflammation in senescent cells

Dou et al. demonstrate that the presence of chromatin in the cytoplasm of senescent cells triggers inflammation and establishes the senescence-associated secretory phenotype (see also Umbreit and Pellman).

STRUCTURAL BIOLOGY

TRPML structures

Three new structural studies by Schmiege et al., Hirschi et al., and Chen et al. elucidate the gating mechanism of transient receptor potential mucolipin (TRPML) cation channels.

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