Editors' ChoiceCellular and Molecular Signaling

Papers of note in Nature 550 (7677)

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Sci. Signal.  31 Oct 2017:
Vol. 10, Issue 503, eaar3249
DOI: 10.1126/scisignal.aar3249

This week’s articles highlight inflammatory memory in epithelial stem cells; ubiquitin-specific protease inhibitors that target cancer cells; the identification of a sphingosine 1-phosphate exporter; and G protein signaling hotspots on the plasma membrane.

INFLAMMATION

Memories of inflammation

Naik et al. report that epithelial stem cells’ ability to “remember” past inflammation depends on the activity of the AIM2 inflammasome (see also Dai and Medzhitov).

CANCER

USP inhibitors induce tumor cell death

Turnbull et al. and Kategaya et al. developed small-molecule inhibitors of the ubiquitin-specific protease USP7 that inhibit tumor growth in mice.

CELL BIOLOGY

S1P exporter identified

Vu et al. show that the transmembrane protein Mfsd2b mediates the release of sphingosine-1-phosphate from platelets and red blood cells.

G protein signaling hot spots

Sungkaworn et al. used single-molecule imaging to demonstrate that G protein–coupled receptors interact with G proteins in defined cell surface domains.

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