Editors' ChoiceImmunology

Papers of note in Science Immunology 2 (16)

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Sci. Signal.  31 Oct 2017:
Vol. 10, Issue 503, eaar3268
DOI: 10.1126/scisignal.aar3268

This month’s articles show how type III interferons mediate antifungal immunity; examine the mechanism of lipid autoreactivity of T cell receptors; and implicate lysosomal signaling in controlling dendritic cell migration.

FUNGAL INFECTION

Type III interferons prime neutrophils

Espinosa et al. showed that type III interferons act on neutrophils to promote the antifungal immune response in mice infected with Aspergillus fumigatus.

AUTOREACTIVITY

Avoiding lipid autoreactivity

Shahine et al. solved the structure of an autoreactive T cell receptor bound to a rare self-phospholipid and gained insights into how these receptors distinguish between rare and abundant self-phospholipids.

DENDRITIC CELLS

Lysosomal calcium powers dendritic cell migration

Bretou et al. found that the release of calcium from the lysosomes of activated dendritic cells was required for their directional migration and chemotaxis to lymph nodes.

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