Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice

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Sci. Signal.  07 Nov 2017:
Vol. 10, Issue 504, eaan0665
DOI: 10.1126/scisignal.aan0665

Article Information

vol. 10 no. 504

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  • Received March 2, 2017
  • Accepted October 18, 2017

Author Information

  1. Emanuela Santini1,2,*,
  2. Thu N. Huynh1,,,
  3. Francesco Longo1,,
  4. So Yeon Koo1,
  5. Edward Mojica1,
  6. Laura D’Andrea3,
  7. Claudia Bagni3,4,5,6, and
  8. Eric Klann1,§
  1. 1Center for Neural Science, New York University, New York, NY 10003, USA.
  2. 2Department of Neurology, Columbia University, New York, NY 10032, USA.
  3. 3Department of Biomedicine and Prevention, University of Rome “Tor Vergata,” 00133 Rome, Italy.
  4. 4Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease, KU Leuven, 3000 Leuven, Belgium.
  5. 5VIB Center for the Biology of Disease, 3000 Leuven, Belgium.
  6. 6Department of Fundamental Neuroscience, University of Lausanne, 1005 Lausanne, Switzerland.
  1. §Corresponding author. Email: eklann{at}
  • * Present address: Department of Neurology, Columbia University, New York, NY 10032, USA.

  • Present address: Brain and Mind Research Institute and Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA.

  • These authors contributed equally to this work.


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