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Papers of note in Science Translational Medicine 9 (414)

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Sci. Signal.  07 Nov 2017:
Vol. 10, Issue 504, eaar3827
DOI: 10.1126/scisignal.aar3827

This week’s articles describe new ways to treat some types of GI cancer and various childhood solid tumors.

CANCER

A targeted KIT inhibitor

Evans et al. show that an active-conformation inhibitor of the kinases KIT and PDGFRA is effective in patients with gastrointestinal cancer.

An Achilles’ heel in childhood cancers

Henssen et al. show that inhibiting nonhomologous end joining–mediated repair of DNA may kill various childhood-associated solid tumors that express the DNA transposase PGBD5.

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