Editors' ChoiceMEDICINE

Papers of note in Science Translational Medicine 9 (415)

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Sci. Signal.  14 Nov 2017:
Vol. 10, Issue 505, eaar4466
DOI: 10.1126/scisignal.aar4466

This week’s articles describe a way to combat the negative effects of stress on cancer therapy; a potential target in heart failure; and why nighttime wounds heal more slowly than daytime wounds.

CANCER

Destressing cancer with β-blockers

Nilsson et al. report that blocking stress hormone signaling on cancer cells with β2-adrenergic receptor inhibitors may boost the therapeutic efficacy of EGFR inhibitors in lung cancer patients.

HEART FAILURE

A fetal gene for heart failure

Van der Pol et al. discovered that inhibiting the expression of a fetal-like gene increases oxidative stress and is cardioprotective in mice.

CIRCADIAN RHYTHMS

Time heals all wounds

Hoyle et al. show that circadian regulation of actin dynamics in migrating fibroblasts affects the speed of wound healing.

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