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Papers of note in Science Translational Medicine 9 (416)

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Sci. Signal.  21 Nov 2017:
Vol. 10, Issue 506, eaar5103
DOI: 10.1126/scisignal.aar5103

This week’s articles describe why pulmonary hypertension often arises with lung cancer; a way to interrupt the autoimmune response in type 1 diabetes; and a marker through which to screen patients for response to MSC therapy and risk for graft-versus-host disease.

CANCER

A tense environment

Pullamsetti et al. report that lung cancer drives vascular remodeling in its microenvironment, resulting in the development of pulmonary hypertension in patients.

AUTOIMMUNITY

Stemming attacks on the pancreas

Ben Nasr et al. demonstrate that gene therapy or pharmacological enhancement of PD-L1 on hematopoietic stem cells could suppress the autoimmune-mediated pancreatic β cell loss in patients with diabetes.

TRANSPLANTATION

MSC sacrifice for immunosuppression

Galleu et al. show that patients could be screened for the capacity of their phagocytes to kill mesenchymal stromal cells to predict their response to a therapeutic transplant.

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